Imaging and Screening Unit

Simona Rodighiero

Unit Coordinator

*Email*	Simona.Rodighiero@ieo.it
*Telephone*	+390294375026
*Location*	Building 1 Floor Ground Via Adamello 16, Milano

The Imaging & Screening Unit provides integrated technological support for cancer research within the Department of Experimental Oncology, combining advanced optical microscopy and automated medium-throughput screening platforms.

Imaging activities cover the full spectrum of optical microscopy — from wide-field to super-resolution — supporting applications from cells and organoids to tissues and in vivo model systems. The Unit assists researchers from experimental design to quantitative image and data analysis.

Screening activities offer open access to automated, plate-based platforms for systematic cellular and biochemical assays, enabling compound testing and functional studies.

Through expertise, training, and collaborative support, the Unit promotes robust, reproducible, and quantitatively driven research.

Discover more about the Imaging activities

Discover more about the Screening activities

Most Relevant Publications

Polizzese D, Mandana GM, Russo M, Polletti S, Prosperini E, Ciossani G, Monzani S, Scietti L, Rodighiero S, Gualdrini F, Piccolo V, Natoli G

Sequence-specific RNA recognition drives Restrictor-mediated termination of extragenic transcription.

Mol Cell, 2026
Eli S, Rauso G, Ghezzi P, Szczerkowski JLA, Bruzzi M, Rizzelli F, Iommazzo F, Loffreda A, Castagna F, Donà F, Gaddoni C, Dondi A, Marenda M, Rodighiero S, Tournier P, Lavagnino Z, Parazzoli D, Gauthier NC, Tamburri S, Pasini D, Habib SJ, Mapelli M

Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria.

Nat Commun, 2025
Di Chiaro P, Nacci L, Arco F, Brandini S, Polletti S, Palamidessi A, Donati B, Soriani C, Gualdrini F, Frigè G, Mazzarella L, Ciarrocchi A, Zerbi A, Spaggiari P, Scita G, Rodighiero S, Barozzi I, Diaferia GR, Natoli G

Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer.

Cancer Cell, 2024
Granieri L, Marocchi F, Melixetian M, Mohammadi N, Nicoli P, Cuomo A, Bonaldi T, Confalonieri S, Pisati F, Giardina G, Bertalot G, Bossi D, Lanfrancone L

Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors.

Cell Rep, 2022

Technological Units

Imaging and Screening Unit

Simona Rodighiero

Most Relevant Publications

Sequence-specific RNA recognition drives Restrictor-mediated termination of extragenic transcription.

Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria.

Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer.

Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors.

Technologist

Fellow Bioinformatician

Lead Technician

Technician