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** 20/05/2026 - h. 14:00
speaker: Roberto Vendramin, BRC NIHR Fellow; Group Leader, RNA Adaptive Responses & Evolution (RARE) lab, UCL Cancer Institute & Visiting Scientist, the Francis Crick Institute, London (UK)
title: Determinants of tumour immune recognition
host: IEO-Amati
location: IFOM Conference Room **

https://profiles.ucl.ac.uk/80748-roberto-vendramin


Dear All,

Roberto did his PhD at VIB-KU Leuven with Jean-Christophe Marine and Eleonora Leucci, where he contributed seminal studies on targeted therapeutic development against melanoma. He was then a postdoc with Charlie Swanton and Kevin Litchfield (Crick Institute and UCL, London) and recently started his independent group at UCL.


The work that he will present, recently published in Immunity (https://doi.org/10.1016/j.immuni.2026.02.005), was a true tour-de-force and a fundamental contribution to the cancer immunology field, in which he demonstrated that inhibiting the nonsense-mediated mRNA decay (NMD) pathway in tumor cells elicits expression and presentation of neoantigens, thus potentiating the therapeutic action of Immune Checkpoint Inhibitors.

I hope to see you at the seminar.
Thank you,
Bruno

Determinants of tumour immune recognition

May 20, 2026 14:00

our last paper

Sequence-specific RNA recognition drives Restrictor-mediated termination of extragenic transcription.

Sequence-specific RNA recognition drives Restrictor-mediated termination of extragenic transcription.

Polizzese D, Mandana GM, Russo M, Polletti S, Prosperini E, Ciossani G, Monzani S, Scietti L, Rodighiero S, Gualdrini F, Piccolo V, Natoli G
Mar , 2026

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