Emanuele Lettera
| emanuele.lettera@ieo.it | |
| Location |
Building 13
Floor 1st Via Adamello 16, Milano |
Emanuele Lettera is a scientist passionate about bringing medical advancements to patients, with extensive 10+ years of international experience in Hematopoietic Stem Cell Biology and Immuno-Oncology from basic research to clinical development in top ranking Institutes in Italy and USA. He received his Bachelor and Master’s degrees in Cellular and Molecular Biology from the University of Rome Tor Vergata. In 2016 he started his PhD in Molecular Medicine under the supervision of Dr. Di Micco at San Raffaele Telethon Institute for Gene Therapy, in Milan, where he worked on two distinct but interrelated projects aiming at dissecting and targeting senescence programs in normal, aged and malignant hematopoiesis. In 2020 he began his postdoctoral training at Memorial Sloan Kettering in New York, in the lab of Dr. Bakhoum. His research focused on tumor-intrinsic and extrinsic mechanisms that allow cancer cells to tolerate and exploit chronic inflammatory signaling, thereby promoting metastasis and therapeutic resistance. Using integrated cell biology, biochemical, murine, and computational approaches, he investigated how sustained activation of the cGAS–STING innate immune pathway contributes to immune evasion, metastasis, and resistance to therapy in human cancer. During his training he received several awards including a Postdoctoral Research Fellowship in Human Oncology and Pathogenesis Program from MSK and the Cancer Research Institute Irvington Postdoctoral Fellowship from CRI.